1/8/2024 0 Comments Transcribe dna to mrnaThe scientists then measured the amount of LINE-1 in the cells and the presence of reverse-transcribed DNA corresponding to the mRNA from the vaccine. This human liver cell line is named Huh7. In the recent study, the scientists added varying amounts of the Pfizer-BioNTech COVID-19 vaccine to a cell culture of human liver cells derived from a hepatocarcinoma (liver cancer). No reference to the study which failed to reproduce the results from Zhang et al. Such a hypothesis, as the authors pointed out, has implications for vaccine safety, as foreign DNA integration into the genome could lead to problems like cancer. at Lund University formulated the hypothesis that reverse-transcribed DNA in SARS-CoV-2-infected cells could also happen in the context of mRNA vaccines. The contention about the study by Zhang et al. It remains unlikely that retrotranscription and integration of the SARS-CoV-2 genome in patients happens at any notable frequency, or even at all.” “ Given the inappropriate interpretation of high-throughput sequencing methods and improper experimental design by the authors, we ask for restraint about the conclusions presented by the study. The letter called for caution in the interpretation of the study: , highlighting several flaws in the experiment, suggesting that the study’s findings were likely due to experimental artifacts rather than a genuine phenomenon. In a letter to PNAS, another group of scientists questioned the conclusions of the study by Zhang et al. controversial was the fact that other scientists weren’t able to reproduce the results. Therefore, viral RNA could in theory be reverse-transcribed into DNA in the presence of reverse transcriptase activity from LINE-1. Reverse transcriptase enables the production of DNA from RNA. This ability is thanks in part to an enzyme called reverse transcriptase, which the LINE-1 element encodes for. Transposable elements, discovered by the geneticist Barbara McClintock, are also known as “jumping genes” because of their ability to move from one place to another in the genome. further reported that the presence of these DNA copies in the genome of the cells was enabled thanks to the action of a transposable element named LINE-1, which is present in human DNA. published in May 2021 in the journal PNAS, in which scientists reported that SARS-CoV-2-infected cells carried DNA copies of the virus’ genetic material. The study, titled “Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Line”, draws on an earlier controversial study by Zhang et al. The foundations of the study and what the study reported This review explains what the study reported, what the findings mean (and what they don’t), and shows why the claim is inaccurate and misleading. And the recent study by Lund University researchers fails to bring evidence to the contrary. The false claim that COVID-19 mRNA vaccines change our DNA has been circulating since mid-2020, as this Health Feedback review documented. Centers for Disease Control and Prevention, as seen from shares of the article here and here. Articles, like this one published by the Epoch Times, also reported on the study in a similar fashion, leading readers to believe the study contradicted statements made by the U.S. In theory, while mRNA in vaccines can be converted into DNA by reverse transcription, there’s no scientific evidence demonstrating that this process occurs in people or that it leads to DNA integration in the genome.įULL CLAIM: “The vaccine’s mRNA converting into DNA and being found inside the cell’s nucleus is something that the Centers for Disease Control and Prevention (CDC) said would not happen.” Vaccine mRNA is incorporated into our genome “This is the first time that researchers have shown in vitro or inside a petri dish how an mRNA vaccine is converted into DNA on a human liver cell line, and is what health experts and fact-checkers said for over a year could not occur.”Ī study published by researchers at Lund University in Sweden made the rounds in late February 2022, with many social media users sharing it as evidence that COVID-19 mRNA vaccines change our DNA (see examples here and here ). ![]() It is mediated by an enzyme known as reverse transcriptase. Reverse transcription is a process by which RNA can be used as a template to produce DNA.
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